Polopiryna Complex – Multi-Symptom Cold & Flu Relief Powder – 8 Sachets

Polopiryna Complex is an over-the-counter medicinal product designed for the comprehensive treatment of multiple symptoms associated with the common cold and flu. It combines acetylsalicylic acid, phenylephrine, and chlorphenamine in a convenient powder sachet that is dissolved in hot water to make an orange-flavored oral drink.

Each sachet contains 500 mg of acetylsalicylic acid, 15.58 mg of phenylephrine bitartrate, equivalent to 8.21 mg of phenylephrine, and 2 mg of chlorphenamine maleate. Together, these active ingredients target several different cold and flu symptoms, including fever, headache, sore throat, muscle and joint aches, nasal congestion, excessive nasal discharge, sneezing, and watery eyes.

The three active ingredients have complementary roles. Acetylsalicylic acid provides analgesic, antipyretic, and anti-inflammatory effects. Phenylephrine helps reduce swelling and congestion of the nasal mucosa, while chlorphenamine helps relieve symptoms of runny nose and sneezing. The powder format is intended to be dissolved in hot water and taken orally.

Click here to explore our other cold, flu, pain relief, respiratory health, and seasonal wellness products!

Key Benefits

• Multi-Symptom Cold & Flu Relief
  Polopiryna Complex is intended for the comprehensive treatment of several symptoms that may occur during a cold or flu, rather than focusing on only one symptom.
• Helps Reduce Fever
  The acetylsalicylic acid component has antipyretic properties and is used to help reduce elevated body temperature associated with acute respiratory infections.
• Relieves Headache and Body Aches
  Acetylsalicylic acid provides analgesic and anti-inflammatory activity that can help relieve headaches as well as muscle and bone-and-joint pain associated with cold and flu symptoms.
• Helps Relieve Nasal Congestion
  Phenylephrine is included to reduce swelling and congestion of the nasal mucosa, helping improve nasal airflow when congestion is present.
• Helps Reduce Runny Nose and Sneezing
  Chlorphenamine is a first-generation antihistamine that helps reduce symptoms such as excessive nasal discharge and sneezing.
• Convenient Hot Drink Format
  Each sachet is dissolved in hot water, creating an orange-flavored drink that can be convenient to take during periods of illness.
• Three Complementary Active Ingredients
  The combination of an analgesic and antipyretic, a nasal decongestant, and an antihistamine allows the medicine to address several cold and flu symptoms in one preparation.

Key Ingredients

• Acetylsalicylic Acid – 500 mg
  Also known as aspirin, acetylsalicylic acid belongs to the non-steroidal anti-inflammatory drug class. In Polopiryna Complex, it provides analgesic, antipyretic, and anti-inflammatory activity.
• Phenylephrine Bitartrate – 15.58 mg
  Each sachet contains 15.58 mg of phenylephrine bitartrate, corresponding to 8.21 mg of phenylephrine. It is included for its vasoconstricting effect on the nasal mucosa and its role in reducing nasal swelling and congestion.
• Chlorphenamine Maleate – 2 mg
  Chlorphenamine is a first-generation H1 antihistamine used to help relieve symptoms such as runny nose and sneezing.
• Orange Flavor and Other Ingredients
  The powder also contains sucrose, anhydrous colloidal silica, sodium saccharin, sodium cyclamate, anhydrous citric acid, and orange flavoring. The orange flavor contains sulfites and butylated hydroxyanisole (E320).

Research

Research on the individual active ingredients provides context for their roles in symptomatic cold and flu treatment. Clinical evidence supports the use of aspirin for relief of fever, headache, and body aches associated with upper respiratory tract infections. However, evidence for oral phenylephrine has been mixed, with systematic reviews reaching different conclusions depending on dose, study design, and outcome measured. First-generation antihistamines such as chlorphenamine may provide some short-term benefit for runny nose and sneezing, although sedation and other adverse effects are important considerations.

These studies evaluate individual ingredients or medication classes rather than the exact Polopiryna Complex formulation, so they should be considered supporting scientific background rather than direct clinical evidence for this specific product.

Research References:

• PubMed – Aspirin Compared With Acetaminophen in Adults With Acute Febrile Upper Respiratory Tract Infection
• PubMed – Efficacy and Safety of Over-the-Counter Analgesics in the Treatment of Common Cold and Flu
• PubMed – Efficacy and Safety of Oral Phenylephrine: Systematic Review and Meta-Analysis
• PubMed – The Use and Efficacy of Oral Phenylephrine Versus Placebo for Nasal Congestion
• PubMed – Antihistamines for the Common Cold

Suggested Use

Polopiryna Complex is intended for adults and adolescents aged 16 years and above.

• Recommended dose: Take 1 sachet every 6–8 hours as needed.
• Maximum daily dose: Do not exceed 4 sachets in 24 hours.
• Daily maximum equivalent: 4 sachets provide a maximum of 2,000 mg acetylsalicylic acid, 32 mg phenylephrine bitartrate, and 8 mg chlorphenamine maleate.
• The medicine is recommended to be taken after a meal.
• Do not exceed the recommended dose.

Polopiryna Complex should be used exactly as described in the patient information leaflet or according to the advice of a doctor or pharmacist.

How to Use

• Empty the contents of one sachet into a glass.
• Add hot water.
• Stir thoroughly until the powder has completely dissolved.
• Drink the prepared solution while warm.
• Take the next dose only after the recommended 6–8 hour interval, when needed.

Do not take a double dose to make up for a missed dose. If too much Polopiryna Complex has been taken, seek medical attention promptly.

Important Information

• For adults and adolescents 16 years and older: Polopiryna Complex should not be given to children or adolescents under 16 years of age.
• Do not combine with other products containing acetylsalicylic acid, phenylephrine, or chlorphenamine. Combining multiple products with the same active ingredients can increase the risk of overdose and adverse effects.
• Do not drink alcohol while taking this medicine. Alcohol may increase gastrointestinal and central nervous system adverse effects.
• May cause drowsiness: Chlorphenamine can cause sleepiness, dizziness, impaired concentration, blurred vision, and slower psychomotor reactions. Avoid driving or operating machinery if these effects occur.
• Pregnancy and breastfeeding: Polopiryna Complex is contraindicated during pregnancy and breastfeeding.
• Aspirin sensitivity: Do not use the medicine if you are allergic to acetylsalicylic acid or have previously experienced aspirin or NSAID-related bronchospasm, asthma, hives, or other hypersensitivity reactions.
• Stomach and intestinal conditions: The medicine should not be used with active peptic ulcers, gastrointestinal inflammation, or gastrointestinal bleeding.
• Heart, blood pressure, kidney, and liver conditions: The product is contraindicated in severe liver, kidney, or heart failure and in certain cardiovascular conditions, including hypertension.
• Other medical conditions: It is contraindicated in conditions including diabetes, closed-angle glaucoma, hyperthyroidism, prostate enlargement, pheochromocytoma, and certain bleeding disorders.
• Blood-thinning medicines: Acetylsalicylic acid can increase bleeding risk when used with anticoagulants, antiplatelet medicines, or certain thrombolytic medicines.
• Methotrexate: Use with methotrexate at doses of 15 mg per week or higher is contraindicated. Lower doses also require medical supervision because of potential toxicity.
• MAO inhibitors: Do not use Polopiryna Complex while taking MAO inhibitors or within 14 days after stopping them.
• Diabetes medicines: The medicine may interact with insulin and certain oral antidiabetic medicines.
• Surgery: The medicine should generally be stopped 5–7 days before planned surgery because acetylsalicylic acid may prolong bleeding time. Discuss this with your doctor before stopping any prescribed medicine.
• Sulfites: The product contains sulfites, which may rarely cause severe hypersensitivity reactions or bronchospasm.
• Sugar: Each sachet contains approximately 2,182 mg of sucrose. This should be taken into account by people with diabetes or those who have been advised to restrict certain sugars.
• Sodium: The product contains less than 23 mg of sodium per sachet and is considered essentially sodium-free.
• Older adults: People over 65 should use Polopiryna Complex with particular caution because dizziness, sedation, confusion, blood pressure changes, slow heart rate, and urinary retention may occur more readily.
• Persistent or worsening symptoms: Consult a doctor or pharmacist if symptoms do not improve or become worse.
• Read the package leaflet carefully before use and consult a healthcare professional when there is any uncertainty about whether this medicine is appropriate.

Product Facts

• Product: Polopiryna Complex
• Type: OTC medicinal product
• Form: Powder for oral solution
• Flavor: Orange
• Quantity: 8 sachets
• Active Ingredient: Acetylsalicylic acid
• Acetylsalicylic Acid: 500 mg per sachet
• Phenylephrine Bitartrate: 15.58 mg per sachet
• Phenylephrine Equivalent: 8.21 mg per sachet
• Chlorphenamine Maleate: 2 mg per sachet
• Age: Adults and adolescents 16 years and older
• Recommended Dose: 1 sachet every 6–8 hours as needed
• Maximum: 4 sachets per day
• Preparation: Dissolve 1 sachet in a glass of hot water
• Storage: Keep below 25°C and out of the sight and reach of children